Inhibition of mTOR signaling protects human glioma cells from hypoxia-induced cell death in an autophagy-independent manner

Although malignant gliomas frequently show aberrant activation of the mammalian target of rapamycin (mTOR), mTOR inhibitors have performed poorly in clinical trials. Besides regulating cell growth and translation, mTOR controls the initiation of autophagy. By recycling cellular components, autophagy...

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Detalles Bibliográficos
Autores principales: Divé, Iris, Klann, Kevin, Michaelis, Jonas B., Heinzen, Dennis, Steinbach, Joachim P., Münch, Christian, Ronellenfitsch, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537540/
https://www.ncbi.nlm.nih.gov/pubmed/36202792
http://dx.doi.org/10.1038/s41420-022-01195-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537540/
https://www.ncbi.nlm.nih.gov/pubmed/36202792
http://dx.doi.org/10.1038/s41420-022-01195-y

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