Amphiphilic aminoglycosides: Modifications that revive old natural product antibiotics

Widely-used Streptomyces-derived antibacterial aminoglycosides have encountered challenges because of antibiotic resistance and toxicity. Today, they are largely relegated to medicinal topical applications. However, chemical modification to amphiphilic aminoglycosides can revive their efficacy again...

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Detalles Bibliográficos
Autores principales: Takemoto, Jon Y., Altenberg, Guillermo A., Poudyal, Naveena, Subedi, Yagya P., Chang, Cheng-Wei T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537547/
https://www.ncbi.nlm.nih.gov/pubmed/36212866
http://dx.doi.org/10.3389/fmicb.2022.1000199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537547/
https://www.ncbi.nlm.nih.gov/pubmed/36212866
http://dx.doi.org/10.3389/fmicb.2022.1000199

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