Impact of genetic polymorphisms of drug transporters ABCB1 and ABCG2 and regulators of xenobiotic transport and metabolism PXR and CAR on clinical efficacy of dasatinib in chronic myeloid leukemia

INTRODUCTION: Functional single-nucleotide polymorphisms (SNPs) in genes regulating cellular uptake, elimination, and metabolism of xenobiotics may potentially influence the outcome of chronic myeloid leukemia (CML) patients treated with BCR-ABL1 tyrosine kinase inhibitors (TKI). Dasatinib, a second...

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Detalles Bibliográficos
Autores principales: Madejczyk, Anna Marta, Canzian, Federico, Góra-Tybor, Joanna, Campa, Daniele, Sacha, Tomasz, Link-Lenczowska, Dorota, Florek, Izabela, Prejzner, Witold, Całbecka, M., Rymko, M., Dudziński, M., Orzechowska, Magdalena Julita, Jamroziak, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537611/
https://www.ncbi.nlm.nih.gov/pubmed/36212403
http://dx.doi.org/10.3389/fonc.2022.952640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537611/
https://www.ncbi.nlm.nih.gov/pubmed/36212403
http://dx.doi.org/10.3389/fonc.2022.952640

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