Requirements for MRN endonuclease processing of topoisomerase II-mediated DNA damage in mammalian cells

During a normal topoisomerase II (TOP2) reaction, the enzyme forms a covalent enzyme DNA intermediate consisting of a 5′ phosphotyrosyl linkage between the enzyme and DNA. While the enzyme typically rejoins the transient breakage after strand passage, a variety of conditions including drugs targetin...

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Detalles Bibliográficos
Autores principales: Sun, Yilun, Soans, Eroica, Mishina, Margarita, Petricci, Elena, Pommier, Yves, Nitiss, Karin C., Nitiss, John L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537633/
https://www.ncbi.nlm.nih.gov/pubmed/36213114
http://dx.doi.org/10.3389/fmolb.2022.1007064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537633/
https://www.ncbi.nlm.nih.gov/pubmed/36213114
http://dx.doi.org/10.3389/fmolb.2022.1007064

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