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Requirements for MRN endonuclease processing of topoisomerase II-mediated DNA damage in mammalian cells
During a normal topoisomerase II (TOP2) reaction, the enzyme forms a covalent enzyme DNA intermediate consisting of a 5′ phosphotyrosyl linkage between the enzyme and DNA. While the enzyme typically rejoins the transient breakage after strand passage, a variety of conditions including drugs targetin...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537633/ https://www.ncbi.nlm.nih.gov/pubmed/36213114 http://dx.doi.org/10.3389/fmolb.2022.1007064 |