Native and activated antithrombin inhibits TMPRSS2 activity and SARS‐CoV‐2 infection

Host cell proteases such as TMPRSS2 are critical determinants of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) tropism and pathogenesis. Here, we show that antithrombin (AT), an endogenous serine protease inhibitor regulating coagulation, is a broad‐spectrum inhibitor of coronavirus i...

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Detalles Bibliográficos
Autores principales: Wettstein, Lukas, Immenschuh, Patrick, Weil, Tatjana, Conzelmann, Carina, Almeida‐Hernández, Yasser, Hoffmann, Markus, Kempf, Amy, Nehlmeier, Inga, Lotke, Rishikesh, Petersen, Moritz, Stenger, Steffen, Kirchhoff, Frank, Sauter, Daniel, Pöhlmann, Stefan, Sanchez‐Garcia, Elsa, Münch, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538173/
https://www.ncbi.nlm.nih.gov/pubmed/36056630
http://dx.doi.org/10.1002/jmv.28124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538173/
https://www.ncbi.nlm.nih.gov/pubmed/36056630
http://dx.doi.org/10.1002/jmv.28124

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