Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs

Pet dogs with naturally occurring cancers play an important role in studies of cancer biology and drug development. We assessed tolerability, efficacy, and pharmacokinetic/pharmacodynamic relationships with a first-in-class small molecule inhibitor of valosin-containing protein (VCP/p97), CB-5339, a...

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Detalles Bibliográficos
Autores principales: LeBlanc, Amy K., Mazcko, Christina N., Fan, Timothy M., Vail, David M., Flesner, Brian K., Bryan, Jeffrey N., Li, Shan, Wang, Feng, Harris, Scott, Vargas, Jesse D., Govindharajulu, Jeevan P., Jaganathan, Soumya, Tomaino, Francesca, Srivastava, Apurva K., Chou, Tsui-Fen, Stott, Gordon M., Covey, Joseph M., Mroczkowski, Barbara, Doroshow, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538592/
https://www.ncbi.nlm.nih.gov/pubmed/35876604
http://dx.doi.org/10.1158/1535-7163.MCT-22-0167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538592/
https://www.ncbi.nlm.nih.gov/pubmed/35876604
http://dx.doi.org/10.1158/1535-7163.MCT-22-0167

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