Decreased DNA Damage and Improved p53 Specificity of RITA Analogs

Reactivation of p53 tumor-suppressor function by small molecules is an attractive strategy to defeat cancer. A potent p53-reactivating molecule RITA, which triggers p53-dependent apoptosis in human tumor cells in vitro and in vivo, exhibits p53-independent cytotoxicity due to modifications by detoxi...

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Detalles Bibliográficos
Autores principales: Zhan, Yue, Zhou, Xiaolei, Peuget, Sylvain, Singh, Madhurendra, Peyser, Brian D., Fan, Zhimin, Selivanova, Galina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538593/
https://www.ncbi.nlm.nih.gov/pubmed/35877475
http://dx.doi.org/10.1158/1535-7163.MCT-22-0119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538593/
https://www.ncbi.nlm.nih.gov/pubmed/35877475
http://dx.doi.org/10.1158/1535-7163.MCT-22-0119

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