Site‐Specific Multi‐Functionalization of the Carrier Protein CRM(197) by Disulfide Rebridging for Conjugate Vaccine Development

Conjugation of an antigen to a carrier protein is widely used for vaccine development. To develop the next generation of conjugate vaccines, we describe here a method for the controlled multi‐functionalization of the widely employed carrier protein CRM(197) with a carbohydrate‐based antigen and an i...

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Detalles Bibliográficos
Autores principales: Trattnig, Nino, Li, Zeshi, Bosman, Gerlof P., Kosma, Paul, Boons, Geert‐Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538913/
https://www.ncbi.nlm.nih.gov/pubmed/36098623
http://dx.doi.org/10.1002/cbic.202200408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538913/
https://www.ncbi.nlm.nih.gov/pubmed/36098623
http://dx.doi.org/10.1002/cbic.202200408

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