Effects of PB‐TURSO on the transcriptional and metabolic landscape of sporadic ALS fibroblasts

OBJECTIVE: ALS is a rapidly progressive, fatal disorder caused by motor neuron degeneration, for which there is a great unmet therapeutic need. AMX0035, a combination of sodium phenylbutyrate (PB) and taurursodiol (TUDCA, TURSO), has shown promising results in early ALS clinical trials, but its mech...

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Detalles Bibliográficos
Autores principales: Fels, Jasmine A., Dash, Jalia, Leslie, Kent, Manfredi, Giovanni, Kawamata, Hibiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539390/
https://www.ncbi.nlm.nih.gov/pubmed/36083004
http://dx.doi.org/10.1002/acn3.51648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539390/
https://www.ncbi.nlm.nih.gov/pubmed/36083004
http://dx.doi.org/10.1002/acn3.51648

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