Generation of a host cell line containing a MAR‐rich landing pad for site‐specific integration and expression of transgenes

In recent years, targeted gene integration (TI) has been introduced as a strategy for the generation of recombinant mammalian cell lines for the production of biotherapeutics. Besides reducing the immense heterogeneity within a pool of recombinant transfectants, TI also aims at shortening the durati...

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Detalles Bibliográficos
Autores principales: Oliviero, Claudia, Hinz, Steffen C., Bogen, Jan P., Kornmann, Henri, Hock, Björn, Kolmar, Harald, Hagens, Gerrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539524/
https://www.ncbi.nlm.nih.gov/pubmed/35396920
http://dx.doi.org/10.1002/btpr.3254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539524/
https://www.ncbi.nlm.nih.gov/pubmed/35396920
http://dx.doi.org/10.1002/btpr.3254

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