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Generation of a host cell line containing a MAR‐rich landing pad for site‐specific integration and expression of transgenes
In recent years, targeted gene integration (TI) has been introduced as a strategy for the generation of recombinant mammalian cell lines for the production of biotherapeutics. Besides reducing the immense heterogeneity within a pool of recombinant transfectants, TI also aims at shortening the durati...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539524/ https://www.ncbi.nlm.nih.gov/pubmed/35396920 http://dx.doi.org/10.1002/btpr.3254 |