Cargando…

MOF negatively regulates estrogen receptor α signaling via CUL4B-mediated protein degradation in breast cancer

Estrogen receptor α (ERα) is the dominant tumorigenesis driver in breast cancer (BC), and ERα-positive BC (ERα+ BC) accounts for more than two-thirds of BC cases. MOF (males absent on the first) is a highly conserved histone acetyltransferase that acetylates lysine 16 of histone H4 (H4K16) and sever...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xu, Yang, Yang, Li, Danyang, Wu, Zhen, Liu, Haoyu, Zhao, Ziyan, Zhu, Hongying, Xie, Fei, Li, Xiangzhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539768/ https://www.ncbi.nlm.nih.gov/pubmed/36212422 http://dx.doi.org/10.3389/fonc.2022.868866

Ejemplares similares

The Histone Acetyltransferase MOF Regulates SIRT1 Expression to Suppress Renal Cell Carcinoma Progression
por: Guo, Renbo, et al.
Publicado: (2022)

Lack of MOF Decreases Susceptibility to Hypoxia and Promotes Multidrug Resistance in Hepatocellular Carcinoma via HIF-1α
por: Wang, Meng, et al.
Publicado: (2021)

Targeted Ubiquitination and Degradation of G-Protein-Coupled Receptor Kinase 5 by the DDB1-CUL4 Ubiquitin Ligase Complex
por: Wu, Ziyan, et al.
Publicado: (2012)

CNST is Characteristic of Leukemia Stem Cells and is Associated With Poor Prognosis in AML
por: Liu, Haoyu, et al.
Publicado: (2022)

MOF Regulates TNK2 Transcription Expression to Promote Cell Proliferation in Thyroid Cancer
por: Li, Danyang, et al.
Publicado: (2020)

MOF upregulates the estrogen receptor α signaling pathway by its acetylase activity in hepatocellular carcinoma
por: Wei, Shan, et al.
Publicado: (2021)

CUL4B Promotes Temozolomide Resistance in Gliomas by Epigenetically Repressing CDNK1A Transcription
por: Ye, Xiang, et al.
Publicado: (2021)

Signal Pathway of Estrogen and Estrogen Receptor in the Development of Thyroid Cancer
por: Liu, Jian, et al.
Publicado: (2021)

Knockdown of LMTK3 in the Endometrioid Adenocarcinoma Cell Line Ishikawa: Inhibition of Growth and Estrogen Receptor α
por: Cai, Guiyang, et al.
Publicado: (2021)

A Novel Prognostic Scoring System Integrating Gene Expressions and Clinicopathological Characteristics to Predict Very Early Relapse in Node-Negative Estrogen Receptor-Positive/HER2-Negative Breast Cancer
por: Lin, Caijin, et al.
Publicado: (2020)

Estrogen/estrogen receptor promotes the proliferation of endometrial carcinoma cells by enhancing hMOF expression
por: Qi, Yue, et al.
Publicado: (2020)

The Isoforms of Estrogen Receptor Alpha and Beta in Thyroid Cancer
por: Gong, Zhongqin, et al.
Publicado: (2022)

Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer
por: Datta, Jharna, et al.
Publicado: (2022)

Arsenic Induces Functional Re-Expression of Estrogen Receptor α by Demethylation of DNA in Estrogen Receptor-Negative Human Breast Cancer
por: Du, Juan, et al.
Publicado: (2012)

Estrogen Receptors and Their Implications in Colorectal Carcinogenesis
por: Caiazza, Francesco, et al.
Publicado: (2015)

Trends in estrogen and progesterone receptors in prostate cancer: a bibliometric analysis
por: Liao, Wenqiang, et al.
Publicado: (2023)

Prognostic Relevance of Estrogen Receptor Status in Circulating Tumor Cells in Breast Cancer Patients Treated With Endocrine Therapy
por: Zhou, Ying, et al.
Publicado: (2022)

Ligand-induced estrogen receptor α degradation by the proteasome: new actors?
por: Calligé, Mathilde, et al.
Publicado: (2006)

Estrogens and Their Receptors in Prostate Cancer: Therapeutic Implications
por: Di Zazzo, Erika, et al.
Publicado: (2018)

Cul3 substrate adaptor SPOP targets Nup153 for degradation
por: Ong, Joseph Y., et al.
Publicado: (2023)

ER-α36 Promotes the Malignant Progression of Cervical Cancer Mediated by Estrogen via HMGA2
por: Wang, Chunyan, et al.
Publicado: (2021)

Miller–Payne Grading and 70-Gene Signature Are Associated With Prognosis of Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Early-Stage Breast Cancer After Neoadjuvant Chemotherapy
por: Wang, Liye, et al.
Publicado: (2021)

miR-452 Reverses Abnormal Glycosylation Modification of ERα and Estrogen Resistance in TNBC (Triple-Negative Breast Cancer) Through Targeting UGT1A1
por: Li, Yan, et al.
Publicado: (2020)

DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation
por: Yi, Juan, et al.
Publicado: (2015)

Toxicoproteomics Disclose Pesticides as Downregulators of TNF-α, IL-1β and Estrogen Receptor Pathways in Breast Cancer Women Chronically Exposed
por: Pizzatti, Luciana, et al.
Publicado: (2020)

Cyanidin-3-o-Glucoside Pharmacologically Inhibits Tumorigenesis via Estrogen Receptor β in Melanoma Mice
por: Liu, Mei, et al.
Publicado: (2019)

Regulation of ERα Stability and Estrogen Signaling in Breast Cancer by HOIL-1
por: Ding, Jianing, et al.
Publicado: (2021)

Functional Genomic Screening Independently Identifies CUL3 as a Mediator of Vemurafenib Resistance via Src-Rac1 Signaling Axis
por: Vanneste, Marion, et al.
Publicado: (2020)

Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes
por: Yu, Qing, et al.
Publicado: (2020)

Prediction of Successful Ovarian Protection Using Gonadotropin-Releasing Hormone Agonists During Chemotherapy in Young Estrogen Receptor-Negative Breast Cancer Patients
por: Lee, Dong-Yun, et al.
Publicado: (2020)

Estrogen receptor α promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice
por: Lai, Yu‐Jie, et al.
Publicado: (2019)

G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Mantle Cell Lymphoma Growth in Preclinical Models
por: Zhou, Lixia, et al.
Publicado: (2021)

PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer
por: WANG, Yang, et al.
Publicado: (2015)

Cul-de-sac : roman /
por: Thériault, Yves
Publicado: (1981)

Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells
por: Sampayo, Rocío G., et al.
Publicado: (2018)

The Proto-Oncogene Int6 Is Essential for Neddylation of Cul1 and Cul3 in Drosophila
por: Rencus-Lazar, Sigal, et al.
Publicado: (2008)

Re-Expression of ERα and AR in Receptor Negative Endocrine Cancers via GSK3 Inhibition
por: Sharma, Vikas, et al.
Publicado: (2022)

Impact of clinicopathological factors on extended endocrine therapy decision making in estrogen receptor–positive breast cancer
por: Chen, Weilin, et al.
Publicado: (2023)

Relationship between telomere length and the prognosis of breast cancer based on estrogen receptor status: A Mendelian randomization study
por: Li, Yilun, et al.
Publicado: (2022)

Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor
por: Mal, Rahul, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ah70c4t8kgoc1vldnf92ot42kp