Methyltransferases: Functions and Applications

In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs,...

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Detalles Bibliográficos
Autores principales: Abdelraheem, Eman, Thair, Benjamin, Varela, Romina Fernández, Jockmann, Emely, Popadić, Désirée, Hailes, Helen C., Ward, John M., Iribarren, Adolfo M., Lewkowicz, Elizabeth S., Andexer, Jennifer N., Hagedoorn, Peter‐Leon, Hanefeld, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539859/
https://www.ncbi.nlm.nih.gov/pubmed/35691829
http://dx.doi.org/10.1002/cbic.202200212
Descripción
Sumario:In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O‐, N‐, C‐ and S‐MTs, their synthetic applications and potential for compound diversification is given.

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