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Methyltransferases: Functions and Applications
In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs,...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539859/ https://www.ncbi.nlm.nih.gov/pubmed/35691829 http://dx.doi.org/10.1002/cbic.202200212 |
| _version_ | 1784803583953207296 |
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| author | Abdelraheem, Eman Thair, Benjamin Varela, Romina Fernández Jockmann, Emely Popadić, Désirée Hailes, Helen C. Ward, John M. Iribarren, Adolfo M. Lewkowicz, Elizabeth S. Andexer, Jennifer N. Hagedoorn, Peter‐Leon Hanefeld, Ulf |
| author_facet | Abdelraheem, Eman Thair, Benjamin Varela, Romina Fernández Jockmann, Emely Popadić, Désirée Hailes, Helen C. Ward, John M. Iribarren, Adolfo M. Lewkowicz, Elizabeth S. Andexer, Jennifer N. Hagedoorn, Peter‐Leon Hanefeld, Ulf |
| author_sort | Abdelraheem, Eman |
| collection | PubMed |
| description | In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O‐, N‐, C‐ and S‐MTs, their synthetic applications and potential for compound diversification is given. |
| format | Online Article Text |
| id | pubmed-9539859 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-95398592022-10-14 Methyltransferases: Functions and Applications Abdelraheem, Eman Thair, Benjamin Varela, Romina Fernández Jockmann, Emely Popadić, Désirée Hailes, Helen C. Ward, John M. Iribarren, Adolfo M. Lewkowicz, Elizabeth S. Andexer, Jennifer N. Hagedoorn, Peter‐Leon Hanefeld, Ulf Chembiochem Reviews In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O‐, N‐, C‐ and S‐MTs, their synthetic applications and potential for compound diversification is given. John Wiley and Sons Inc. 2022-07-05 2022-09-16 /pmc/articles/PMC9539859/ /pubmed/35691829 http://dx.doi.org/10.1002/cbic.202200212 Text en © 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Reviews Abdelraheem, Eman Thair, Benjamin Varela, Romina Fernández Jockmann, Emely Popadić, Désirée Hailes, Helen C. Ward, John M. Iribarren, Adolfo M. Lewkowicz, Elizabeth S. Andexer, Jennifer N. Hagedoorn, Peter‐Leon Hanefeld, Ulf Methyltransferases: Functions and Applications |
| title | Methyltransferases: Functions and Applications |
| title_full | Methyltransferases: Functions and Applications |
| title_fullStr | Methyltransferases: Functions and Applications |
| title_full_unstemmed | Methyltransferases: Functions and Applications |
| title_short | Methyltransferases: Functions and Applications |
| title_sort | methyltransferases: functions and applications |
| topic | Reviews |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539859/ https://www.ncbi.nlm.nih.gov/pubmed/35691829 http://dx.doi.org/10.1002/cbic.202200212 |
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