Cystine Knot Peptides with Tuneable Activity and Mechanism

Knottins are topologically complex peptides that are stabilised by a cystine knot and have exceptionally diverse functions, including protease inhibition. However, approaches for tuning their activity in situ are limited. Here, we demonstrate separate approaches for tuning the activity of knottin pr...

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Detalles Bibliográficos
Autores principales: Li, Choi Yi, Rehm, Fabian B. H., Yap, Kuok, Zdenek, Christina N., Harding, Maxim D., Fry, Bryan G., Durek, Thomas, Craik, David J., de Veer, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539897/
https://www.ncbi.nlm.nih.gov/pubmed/35224831
http://dx.doi.org/10.1002/anie.202200951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539897/
https://www.ncbi.nlm.nih.gov/pubmed/35224831
http://dx.doi.org/10.1002/anie.202200951

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