Copper bis(thiosemicarbazone) complexes modulate P‐glycoprotein expression and function in human brain microvascular endothelial cells

P‐glycoprotein (P‐gp) is an efflux transporter at the blood–brain barrier (BBB) that hinders brain access of substrate drugs and clears endogenous molecules such as amyloid beta (Aβ) from the brain. As biometals such as copper (Cu) modulate many neuronal signalling pathways linked to P‐gp regulation...

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Detalles Bibliográficos
Autores principales: Pyun, Jae, McInnes, Lachlan E., Donnelly, Paul S., Mawal, Celeste, Bush, Ashley I., Short, Jennifer L., Nicolazzo, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540023/
https://www.ncbi.nlm.nih.gov/pubmed/35304760
http://dx.doi.org/10.1111/jnc.15609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540023/
https://www.ncbi.nlm.nih.gov/pubmed/35304760
http://dx.doi.org/10.1111/jnc.15609

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