Survival analyses from the CENTAUR trial in amyotrophic lateral sclerosis: Evaluating the impact of treatment crossover on outcomes

INTRODUCTION/AIMS: Trials incorporating placebo‐to‐active treatment crossover are encouraged in fatal conditions like amyotrophic lateral sclerosis (ALS) but may underestimate active treatment survival benefit. Here, we apply methods for modeling survival without crossover, including the rank‐preser...

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Detalles Bibliográficos
Autores principales: Paganoni, Sabrina, Watkins, Claire, Cawson, Matthew, Hendrix, Suzanne, Dickson, Samuel P., Knowlton, Newman, Timmons, Jamie, Manuel, Machelle, Cudkowicz, Merit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Clinical Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540225/
https://www.ncbi.nlm.nih.gov/pubmed/35508892
http://dx.doi.org/10.1002/mus.27569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540225/
https://www.ncbi.nlm.nih.gov/pubmed/35508892
http://dx.doi.org/10.1002/mus.27569

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