Cargando…

Survival analyses from the CENTAUR trial in amyotrophic lateral sclerosis: Evaluating the impact of treatment crossover on outcomes

INTRODUCTION/AIMS: Trials incorporating placebo‐to‐active treatment crossover are encouraged in fatal conditions like amyotrophic lateral sclerosis (ALS) but may underestimate active treatment survival benefit. Here, we apply methods for modeling survival without crossover, including the rank‐preser...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paganoni, Sabrina, Watkins, Claire, Cawson, Matthew, Hendrix, Suzanne, Dickson, Samuel P., Knowlton, Newman, Timmons, Jamie, Manuel, Machelle, Cudkowicz, Merit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Clinical Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540225/ https://www.ncbi.nlm.nih.gov/pubmed/35508892 http://dx.doi.org/10.1002/mus.27569

Ejemplares similares

Long‐term survival of participants in the CENTAUR trial of sodium phenylbutyrate‐taurursodiol in amyotrophic lateral sclerosis
por: Paganoni, Sabrina, et al.
Publicado: (2020)

Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial
por: Paganoni, Sabrina, et al.
Publicado: (2022)

Military Service and Amyotrophic Lateral Sclerosis in a Population-based Cohort
por: Weisskopf, Marc G., et al.
Publicado: (2015)

Serum Ferritin and Metal Levels as Risk Factors for Amyotrophic Lateral Sclerosis
por: Qureshi, Muddasir, et al.
Publicado: (2008)

Pilot trial of inosine to elevate urate levels in amyotrophic lateral sclerosis
por: Nicholson, Katharine, et al.
Publicado: (2018)

Enhanced Bulbar Function in Amyotrophic Lateral Sclerosis: The Nuedexta Treatment Trial
por: Smith, Richard, et al.
Publicado: (2017)

Addressing heterogeneity in amyotrophic lateral sclerosis CLINICAL TRIALS
por: Goyal, Namita A., et al.
Publicado: (2020)

Apolipoprotein B-100-mediated motor neuron degeneration in sporadic amyotrophic lateral sclerosis
por: Wong, Jamie K, et al.
Publicado: (2022)

Improving clinical trial outcomes in amyotrophic lateral sclerosis
por: Kiernan, Matthew C., et al.
Publicado: (2020)

Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis
por: Thonhoff, Jason R., et al.
Publicado: (2022)

Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis
por: Alshikho, Mohamad J., et al.
Publicado: (2016)

Antibody Response to HML‐2 May Be Protective in Amyotrophic Lateral Sclerosis
por: Garcia‐Montojo, Marta, et al.
Publicado: (2022)

Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial
por: Babu, Suma, et al.
Publicado: (2021)

Cromolyn sodium delays disease onset and is neuroprotective in the SOD1(G93A) Mouse Model of amyotrophic lateral sclerosis
por: Granucci, Eric J., et al.
Publicado: (2019)

The centaur's smile : the human animal in early Greek art
por: Padgett, J. Michael

IL6 receptor(358)Ala variant and trans-signaling are disease modifiers in amyotrophic lateral sclerosis
por: Wosiski-Kuhn, Marlena, et al.
Publicado: (2019)

Stratification of amyotrophic lateral sclerosis patients: a crowdsourcing approach
por: Kueffner, Robert, et al.
Publicado: (2019)

Radicava/Edaravone Findings in Biomarkers From Amyotrophic Lateral Sclerosis (REFINE-ALS): Protocol and Study Design
por: Berry, James, et al.
Publicado: (2021)

Amyotrophic Lateral Sclerosis: An Emerging Era of Collaborative Gene Discovery
por: Gwinn, Katrina, et al.
Publicado: (2007)

Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [(11)C]-PBR28
por: Zürcher, Nicole R., et al.
Publicado: (2015)

Phase 2B randomized controlled trial of NP001 in amyotrophic lateral sclerosis: Pre‐specified and post hoc analyses
por: Miller, Robert G., et al.
Publicado: (2022)

An expanded access protocol of RT001 in amyotrophic lateral sclerosis—Initial experience with a lipid peroxidation inhibitor
por: Yerton, Megan, et al.
Publicado: (2022)

Initial Identification of a Blood-Based Chromosome Conformation Signature for Aiding in the Diagnosis of Amyotrophic Lateral Sclerosis
por: Salter, Matthew, et al.
Publicado: (2018)

Amyotrophic lateral sclerosis
por: Wijesekera, Lokesh C, et al.
Publicado: (2009)

Design and Initial Results of a Multi-Phase Randomized Trial of Ceftriaxone in Amyotrophic Lateral Sclerosis
por: Berry, James D., et al.
Publicado: (2013)

Imaging of glia activation in people with primary lateral sclerosis
por: Paganoni, Sabrina, et al.
Publicado: (2017)

Amyotrophic lateral sclerosis and neuroregeneration
Publicado: (2012)

Mimickers of Amyotrophic Lateral Sclerosis
por: Dubey, Ayush, et al.
Publicado: (2019)

Destination Amyotrophic Lateral Sclerosis
por: Keon, Matt, et al.
Publicado: (2021)

Prionoids in amyotrophic lateral sclerosis
por: Gosset, Philippe, et al.
Publicado: (2022)

Amyotrophic lateral sclerosis and cerebellum
por: Kabiljo, Renata, et al.
Publicado: (2022)

Dysautonomia in Amyotrophic Lateral Sclerosis
por: Oprisan, Alexandra L., et al.
Publicado: (2023)

Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis
por: Rizzo, Federica, et al.
Publicado: (2013)

Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics – An AI-Enabled Biological Target Discovery Platform
por: Pun, Frank W., et al.
Publicado: (2022)

The centaur's dilemma: national security law for the coming AI revolution
por: Baker, James E
Publicado: (2020)

Centaur antibodies: Engineered chimeric equine-human recombinant antibodies
por: Rosenfeld, Ronit, et al.
Publicado: (2022)

Antecedent Disease and Amyotrophic Lateral Sclerosis: What Is Protecting Whom?
por: Hollinger, Sabrina K., et al.
Publicado: (2016)

Adjusted cost analysis of video televisits for the care of people with amyotrophic lateral sclerosis
por: Paganoni, Sabrina, et al.
Publicado: (2019)

Clinical Psychology and Amyotrophic Lateral Sclerosis
por: Pagnini, Francesco, et al.
Publicado: (2010)

Glial Cells in Amyotrophic Lateral Sclerosis
por: Lasiene, Jurate, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_q176925s1g1qe1tsnsdumi3e2c