Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip(®) assay in TK6 cells

Genotoxicity testing relies on the detection of gene mutations and chromosome damage and has been used in the genetic safety assessment of drugs and chemicals for decades. However, the results of standard genotoxicity tests are often difficult to interpret due to lack of mode of action information....

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Detalles Bibliográficos
Autores principales: Buick, Julie K., Rowan-Carroll, Andrea, Gagné, Rémi, Williams, Andrew, Chen, Renxiang, Li, Heng-Hong, Fornace, Albert J., Chao, Christy, Engelward, Bevin P., Frötschl, Roland, Ellinger-Ziegelbauer, Heidrun, Pettit, Syril D., Aubrecht, Jiri, Yauk, Carole L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540394/
https://www.ncbi.nlm.nih.gov/pubmed/36211197
http://dx.doi.org/10.3389/ftox.2022.991590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540394/
https://www.ncbi.nlm.nih.gov/pubmed/36211197
http://dx.doi.org/10.3389/ftox.2022.991590

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