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Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip(®) assay in TK6 cells
Genotoxicity testing relies on the detection of gene mutations and chromosome damage and has been used in the genetic safety assessment of drugs and chemicals for decades. However, the results of standard genotoxicity tests are often difficult to interpret due to lack of mode of action information....
Autores principales: | Buick, Julie K., Rowan-Carroll, Andrea, Gagné, Rémi, Williams, Andrew, Chen, Renxiang, Li, Heng-Hong, Fornace, Albert J., Chao, Christy, Engelward, Bevin P., Frötschl, Roland, Ellinger-Ziegelbauer, Heidrun, Pettit, Syril D., Aubrecht, Jiri, Yauk, Carole L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540394/ https://www.ncbi.nlm.nih.gov/pubmed/36211197 http://dx.doi.org/10.3389/ftox.2022.991590 |
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