Applying Modeling and Simulations for Rational Dose Selection of Novel Toll‐Like Receptor 7/8 Inhibitor Enpatoran for Indications of High Medical Need

Dual toll‐like receptor (TLR) 7 and TLR8 inhibitor enpatoran is under investigation as a treatment for lupus and coronavirus disease 2019 (COVID‐19) pneumonia. Population pharmacokinetic/pharmacodynamic (PopPK/PD) model‐based simulations, using PK and PD (inhibition of ex vivo‐stimulated interleukin...

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Detalles Bibliográficos
Autores principales: Klopp‐Schulze, Lena, Shaw, Jamie V., Dong, Jennifer Q., Khandelwal, Akash, Vazquez‐Mateo, Cristina, Goteti, Kosalaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540480/
https://www.ncbi.nlm.nih.gov/pubmed/35390178
http://dx.doi.org/10.1002/cpt.2606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540480/
https://www.ncbi.nlm.nih.gov/pubmed/35390178
http://dx.doi.org/10.1002/cpt.2606

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