Effect of Chronic Kidney Disease on the Renal Secretion via Organic Anion Transporters 1/3: Implications for Physiologically‐Based Pharmacokinetic Modeling and Dose Adjustment

There is growing evidence that active tubular secretory clearance (CL(s)) may not decline proportionally with the glomerular filtration rate (GFR) in chronic kidney disease (CKD), leading to the overestimation of renal clearance (CL(r)) when using solely GFR to approximate disease effect on renal el...

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Detalles Bibliográficos
Autores principales: Tan, Shawn Pei Feng, Scotcher, Daniel, Rostami‐Hodjegan, Amin, Galetin, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540491/
https://www.ncbi.nlm.nih.gov/pubmed/35569107
http://dx.doi.org/10.1002/cpt.2642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540491/
https://www.ncbi.nlm.nih.gov/pubmed/35569107
http://dx.doi.org/10.1002/cpt.2642

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