Cargando…

Transferrin receptor 2 (Tfr2) genetic deletion makes transfusion‐independent a murine model of transfusion‐dependent β‐thalassemia

β‐thalassemia is a genetic disorder caused by mutations in the β‐globin gene, and characterized by anemia, ineffective erythropoiesis and iron overload. Patients affected by the most severe transfusion‐dependent form of the disease (TDT) require lifelong blood transfusions and iron chelation therapy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Modica, Simona Maria, Tanzi, Emanuele, Olivari, Violante, Lidonnici, Maria Rosa, Pettinato, Mariateresa, Pagani, Alessia, Tiboni, Francesca, Furiosi, Valeria, Silvestri, Laura, Ferrari, Giuliana, Rivella, Stefano, Nai, Antonella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540808/ https://www.ncbi.nlm.nih.gov/pubmed/36071579 http://dx.doi.org/10.1002/ajh.26673

Ejemplares similares

P1509: BONE MARROW TFR2 GENETIC DELETION ABROGATES BLOOD TRANFUSION REQUIREMENT IN THE HBBTH1/TH2 Β-THALASSEMIC MURINE MODEL
por: Di Modica, S. M., et al.
Publicado: (2022)

S282: ERYTHROPOIESIS INDUCTION THROUGH BONE MARROW TFR2 DELETION REDUCES BLOOD GLUCOSE LEVELS IN WILD-TYPE AND Β-THALASSEMIC MICE
por: Maria DI Modica, Simona, et al.
Publicado: (2023)

NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice
por: Nai, Antonella, et al.
Publicado: (2020)

The extrahepatic role of TFR2 in iron homeostasis
por: Silvestri, Laura, et al.
Publicado: (2014)

Managing the Dual Nature of Iron to Preserve Health
por: Silvestri, Laura, et al.
Publicado: (2023)

S285: DISSECTING THE ROLE OF THE IMMUNOPHILIN FKBP12 IN HEPCIDIN REGULATION
por: Pettinato, Mariateresa, et al.
Publicado: (2023)

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
por: Bien-Ly, Nga, et al.
Publicado: (2014)

Correlation of Transferrin Saturation and Serum Ferritin with Bone Mass Density in Adult Transfusion Dependent Beta-Thalassemia Patients
por: Atmakusuma, Tubagus Djumhana, et al.
Publicado: (2021)

Expression of transferrin receptor‐1 (TFR‐1) in canine osteosarcomas
por: De Vico, Gionata, et al.
Publicado: (2020)

Pulmonary Functions in Transfusion-Dependent Thalassemia
por: Chandra, Jagdish, et al.
Publicado: (2022)

Non-Transfusion-Dependent Thalassemia: An Update on Complications and Management
por: Sleiman, Joseph, et al.
Publicado: (2018)

Hemorheological profiles and chronic inflammation markers in transfusion-dependent and non-transfusion- dependent thalassemia
por: Caprari, Patrizia, et al.
Publicado: (2023)

S270: TRANSFUSION INDEPENDENCE AFTER EXAGAMGLOGENE AUTOTEMCEL IN PATIENTS WITH TRANSFUSION-DEPENDENT ΒETA-THALASSEMIA
por: Locatelli, Franco, et al.
Publicado: (2023)

Alloimmunization among transfusion-dependent thalassemia patients
por: Sadeghian, Mohammad Hadi, et al.
Publicado: (2009)

Glomerular and Tubular Functions in Transfusion-Dependent Thalassemia
por: Sookaromdee, Pathum, et al.
Publicado: (2018)

Quality of life in transfusion-dependent thalassemia patients
por: Alzahrani, Rizqallah A., et al.
Publicado: (2017)

Hypoparathyroidism in a Case of Transfusion Dependent Thalassemia
por: Majumder, Anirban, et al.
Publicado: (2020)

Transfusion Complications in Thalassemia: Patient Knowledge and Perspectives
por: Patterson, Sashoy, et al.
Publicado: (2022)

The transfusion management of beta thalassemia in the United States
por: Lal, Ashutosh, et al.
Publicado: (2021)

Study on effectiveness of transfusion program in thalassemia major patients receiving multiple blood transfusions at a transfusion centre in Western India
por: Shah, Neeraj, et al.
Publicado: (2010)

5588005 IMPACT OF COVID-19 PANDEMIC TO PRE-TRANSFUSION HEMOGLOBIN LEVEL AND FREQUENCY OF TRANSFUSION IN TRANSFUSION-DEPENDENT THALASSEMIA PATIENTS IN INDONESIA
por: Dewi, M.K.D., et al.
Publicado: (2023)

SARS-CoV-2 antibody response in transfusion-dependent thalassemia
por: Kumari, Nidhi, et al.
Publicado: (2021)

Marital status and paternity in patients with Transfusion-Dependent Thalassemia (TDT) and Non Transfusion-Dependent Thalassemia (NTDT): an ICET - A survey in different countries
por: De Sanctis, Vincenzo, et al.
Publicado: (2019)

P1510: VAMIFEPORT PREVENTED THE FORMATION OF NON-TRANSFERRIN-BOUND IRON IN A MOUSE MODEL OF ΒETA-THALASSEMIA WITH BLOOD TRANSFUSIONS
por: Kalleda, N., et al.
Publicado: (2022)

Iron Overload and Chelation Therapy in Non-Transfusion Dependent Thalassemia
por: Bou-Fakhredin, Rayan, et al.
Publicado: (2017)

Luspatercept for transfusion-dependent β-thalassemia: time to get real
por: Musallam, Khaled M., et al.
Publicado: (2023)

Hydroxyurea Treatment in Transfusion-Dependent β-Thalassemia Patients
por: Bordbar, Mohammad Reza, et al.
Publicado: (2014)

Osteoporosis-osteopenia syndrome in children with transfusion dependent thalassemia
por: Ong, Zhi-Miin, et al.
Publicado: (2015)

Ocular abnormalities in multi-transfused beta-thalassemia patients
por: Jafari, Reza, et al.
Publicado: (2015)

Leukocyte telomere length in patients with transfusion-dependent thalassemia
por: Nanthatanti, Nithita, et al.
Publicado: (2020)

Occult Kidney Dysfunction in Children With Transfusion-Dependent Thalassemia
por: Mohd Zikre, Nurwahida, et al.
Publicado: (2021)

Luspatercept‐induced reduction in transfusion requirement in α‐thalassemia
por: Jackson, Nicholas, et al.
Publicado: (2020)

Non-Transfusion-Dependent Thalassemia: A Panoramic Review
por: Shash, Hwazen
Publicado: (2022)

Profile of deferasirox for the treatment of patients with non-transfusion-dependent thalassemia syndromes
por: Ricchi, Paolo, et al.
Publicado: (2015)

A prospective study for prevalence and/or development of transfusion-transmitted infections in multiply transfused thalassemia major patients
por: Jain, Roopam, et al.
Publicado: (2012)

In Situ Proximity Ligation Assays Indicate That Hemochromatosis Proteins Hfe and Transferrin Receptor 2 (Tfr2) Do Not Interact
por: Rishi, Gautam, et al.
Publicado: (2013)

Beta Thalassemia: New Therapeutic Options Beyond Transfusion and Iron Chelation
por: Motta, Irene, et al.
Publicado: (2020)

2021 Thalassaemia International Federation Guidelines for the Management of Transfusion-dependent Thalassemia
por: Farmakis, Dimitrios, et al.
Publicado: (2022)

β-Thalassemia Mutations among Transfusion-Dependent Thalassemia Major Patients in Northern Iraq
por: Al-Allawi, Nasir A. S., et al.
Publicado: (2010)

Mutational analysis of thalassemia in transfusion-dependent beta-thalassemia patients from central India
por: Shrivastava, Manisha, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ukuhelf2j1ki60ifrv3jdren23