Proteomic analysis of the IPF mesenchymal progenitor cell nuclear proteome identifies abnormalities in key nodal proteins that underlie their fibrogenic phenotype

IPF is a progressive fibrotic lung disease whose pathogenesis remains incompletely understood. We have previously discovered pathologic mesenchymal progenitor cells (MPCs) in the lungs of IPF patients. IPF MPCs display a distinct transcriptome and create sustained interstitial fibrosis in immune def...

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Detalles Bibliográficos
Autores principales: Yang, Libang, Gilbertsen, Adam, Smith, Karen, Xia, Hong, Higgins, LeeAnn, Guerrero, Candace, Henke, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541064/
https://www.ncbi.nlm.nih.gov/pubmed/35633524
http://dx.doi.org/10.1002/pmic.202200018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541064/
https://www.ncbi.nlm.nih.gov/pubmed/35633524
http://dx.doi.org/10.1002/pmic.202200018

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