Carba Analogues of Flupirtine and Retigabine with Improved Oxidation Resistance and Reduced Risk of Quinoid Metabolite Formation

The K(V)7 potassium channel openers flupirtine and retigabine have been valuable options in the therapy of pain and epilepsy. However, as a result of adverse reactions, both drugs are currently no longer in therapeutic use. The flupirtine‐induced liver injury and the retigabine linked tissue discolo...

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Detalles Bibliográficos
Autores principales: Wurm, Konrad W., Bartz, Frieda‐Marie, Schulig, Lukas, Bodtke, Anja, Bednarski, Patrick J., Link, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541272/
https://www.ncbi.nlm.nih.gov/pubmed/35687532
http://dx.doi.org/10.1002/cmdc.202200262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541272/
https://www.ncbi.nlm.nih.gov/pubmed/35687532
http://dx.doi.org/10.1002/cmdc.202200262

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