Effect of Colonic Absorption on the Pharmacokinetic Properties of Delayed‐Release and Extended‐Release Methylphenidate: In Vivo, In Vitro, and Modeling Evaluations

Most stimulants used to treat attention‐deficit/hyperactivity disorder are administered in the morning and absorbed in the upper gastrointestinal tract. DR/ER‐MPH (formerly HLD200), an evening‐dosed delayed‐release and extended‐release methylphenidate, is predicted to be absorbed in the proximal col...

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Detalles Bibliográficos
Autores principales: Incledon, Bev, Incledon, Chantal, Gomeni, Roberto, Uchida, Cassandra L., Morris, Amy, Perry, Kim, Kapuscinski, Jill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541386/
https://www.ncbi.nlm.nih.gov/pubmed/35316579
http://dx.doi.org/10.1002/cpdd.1089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541386/
https://www.ncbi.nlm.nih.gov/pubmed/35316579
http://dx.doi.org/10.1002/cpdd.1089

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