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Understanding the interaction of 14‐3‐3 proteins with hDMX and hDM2: a structural and biophysical study
p53 plays a critical role in regulating diverse biological processes: DNA repair, cell cycle arrest, apoptosis and senescence. The p53 pathway has therefore served as the focus of multiple drug‐discovery efforts. p53 is negatively regulated by hDMX and hDM2; prior studies have identified 14‐3‐3 prot...
Autores principales: | Srdanović, Sonja, Wolter, Madita, Trinh, Chi H., Ottmann, Christian, Warriner, Stuart L., Wilson, Andrew J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541495/ https://www.ncbi.nlm.nih.gov/pubmed/35286747 http://dx.doi.org/10.1111/febs.16433 |
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