Integrated continuous biomanufacturing on pilot scale for acid‐sensitive monoclonal antibodies

In this study, we demonstrated the first, to our knowledge, integrated continuous bioprocess (ICB) designed for the production of acid‐sensitive monoclonal antibodies, prone to aggregate at low pH, on pilot scale. A high cell density perfusion culture, stably maintained at 100 × 10(6) cells/ml, was...

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Detalles Bibliográficos
Autores principales: Schwarz, Hubert, Gomis‐Fons, Joaquín, Isaksson, Madelène, Scheffel, Julia, Andersson, Niklas, Andersson, Andreas, Castan, Andreas, Solbrand, Anita, Hober, Sophia, Nilsson, Bernt, Chotteau, Veronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541590/
https://www.ncbi.nlm.nih.gov/pubmed/35470430
http://dx.doi.org/10.1002/bit.28120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541590/
https://www.ncbi.nlm.nih.gov/pubmed/35470430
http://dx.doi.org/10.1002/bit.28120

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