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Integrated continuous biomanufacturing on pilot scale for acid‐sensitive monoclonal antibodies
In this study, we demonstrated the first, to our knowledge, integrated continuous bioprocess (ICB) designed for the production of acid‐sensitive monoclonal antibodies, prone to aggregate at low pH, on pilot scale. A high cell density perfusion culture, stably maintained at 100 × 10(6) cells/ml, was...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541590/ https://www.ncbi.nlm.nih.gov/pubmed/35470430 http://dx.doi.org/10.1002/bit.28120 |