Imidazole and nitroimidazole derivatives as NADH‐fumarate reductase inhibitors: Density functional theory studies, homology modeling, and molecular docking

Chagas disease is caused by Trypanosoma cruzi. Benznidazole and nifurtimox are drugs used for its therapy; nevertheless, they have collateral effects. NADH‐fumarate (FUM) reductase is a potential pharmacological target since it is essential for survival of parasite and is not found in humans. The ob...

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Detalles Bibliográficos
Autores principales: Campos‐Fernández, Linda, Ortiz‐Muñiz, Rocío, Cortés‐Barberena, Edith, Mares‐Sámano, Sergio, Garduño‐Juárez, Ramón, Soriano‐Correa, Catalina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541967/
https://www.ncbi.nlm.nih.gov/pubmed/35796405
http://dx.doi.org/10.1002/jcc.26959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541967/
https://www.ncbi.nlm.nih.gov/pubmed/35796405
http://dx.doi.org/10.1002/jcc.26959

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