Antithrombin‐III mitigates thrombin‐mediated endothelial cell contraction and sickle red blood cell adhesion in microscale flow

Individuals with sickle cell disease (SCD) have persistently elevated thrombin generation that results in a state of systemic hypercoagulability. Antithrombin‐III (ATIII), an endogenous serine protease inhibitor, inhibits several enzymes in the coagulation cascade, including thrombin. Here, we utili...

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Detalles Bibliográficos
Autores principales: Wulftange, William J., Kucukal, Erdem, Man, Yuncheng, An, Ran, Monchamp, Karamoja, Sevrain, Charlotte D., Dashora, Himanshu R., Owusu‐Ansah, Amma T., Bode, Allison, Ilich, Anton, Little, Jane A., Key, Nigel S., Gurkan, Umut A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Haemoglobinopathies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542057/
https://www.ncbi.nlm.nih.gov/pubmed/35822297
http://dx.doi.org/10.1111/bjh.18328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542057/
https://www.ncbi.nlm.nih.gov/pubmed/35822297
http://dx.doi.org/10.1111/bjh.18328

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