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Antithrombin‐III mitigates thrombin‐mediated endothelial cell contraction and sickle red blood cell adhesion in microscale flow
Individuals with sickle cell disease (SCD) have persistently elevated thrombin generation that results in a state of systemic hypercoagulability. Antithrombin‐III (ATIII), an endogenous serine protease inhibitor, inhibits several enzymes in the coagulation cascade, including thrombin. Here, we utili...
Autores principales: | Wulftange, William J., Kucukal, Erdem, Man, Yuncheng, An, Ran, Monchamp, Karamoja, Sevrain, Charlotte D., Dashora, Himanshu R., Owusu‐Ansah, Amma T., Bode, Allison, Ilich, Anton, Little, Jane A., Key, Nigel S., Gurkan, Umut A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542057/ https://www.ncbi.nlm.nih.gov/pubmed/35822297 http://dx.doi.org/10.1111/bjh.18328 |
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