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Multivalent γ‐PGA‐Exendin‐4 Conjugates to Target Pancreatic β‐Cells

Targeting of glucagon‐like peptide 1 receptor (GLP‐1R), expressed on the surface of pancreatic β‐cells, is of great interest for the development of advanced therapies for diabetes and diagnostics for insulinoma. We report the conjugation of exendin‐4 (Ex‐4), an approved drug to treat type 2 diabetes...

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Detalles Bibliográficos
Autores principales: Rossi, Lorenzo, Kerekes, Krisztina, Kovács‐Kocsi, Judit, Körhegyi, Zoltán, Bodnár, Magdolna, Fazekas, Erika, Prépost, Eszter, Pignatelli, Cataldo, Caneva, Enrico, Nicotra, Francesco, Russo, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542156/
https://www.ncbi.nlm.nih.gov/pubmed/35762648
http://dx.doi.org/10.1002/cbic.202200196