The impact of forced degradation conditions on mAb dimer formation and subsequent influence on aggregation propensity

Monoclonal antibody (mAb) aggregation can present major challenges for the development of biotherapeutics. An understanding of the molecular mechanisms of mAb aggregation is highly desirable both because it allows the performance of informed risk assessments regarding the criticality of mAb aggregat...

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Detalles Bibliográficos
Autores principales: Knight, Michael J., Floret, Léontine, Patel, Nisha, O’Hara, John, Rodriguez, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542281/
https://www.ncbi.nlm.nih.gov/pubmed/36198003
http://dx.doi.org/10.1080/19420862.2022.2127172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542281/
https://www.ncbi.nlm.nih.gov/pubmed/36198003
http://dx.doi.org/10.1080/19420862.2022.2127172

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