Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart

Although attenuated IGF1R (insulin-like growth factor 1 receptor) signaling has long been viewed to promote longevity in model organisms, adverse effects on the heart have been the subject of major concern. We observed that IGF1R is overexpressed in cardiac tissues from patients with end-stage non-i...

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Detalles Bibliográficos
Autores principales: Abdellatif, Mahmoud, Madeo, Frank, Kroemer, Guido, Sedej, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Autophagic Punctum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542397/
https://www.ncbi.nlm.nih.gov/pubmed/35786404
http://dx.doi.org/10.1080/15548627.2022.2095835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542397/
https://www.ncbi.nlm.nih.gov/pubmed/35786404
http://dx.doi.org/10.1080/15548627.2022.2095835

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