Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors

A new series of 5-trifluoromethylpyrimidine derivatives were designed and synthesised as EGFR inhibitors. Three tumour cells A549, MCF-7, PC-3 and EGFR kinase were employed to evaluate their biological activities. The results were shown that most of the target compounds existed excellent antitumor a...

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Detalles Bibliográficos
Autores principales: Zuo, Yaqing, Li, Rongrong, Zhang, Yan, Bao, Guochen, Le, Yi, Yan, Longjia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542405/
https://www.ncbi.nlm.nih.gov/pubmed/36176072
http://dx.doi.org/10.1080/14756366.2022.2128797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542405/
https://www.ncbi.nlm.nih.gov/pubmed/36176072
http://dx.doi.org/10.1080/14756366.2022.2128797

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