Silk fibers assisted long-term 3D culture of human primary urinary stem cells via inhibition of senescence-associated genes: Potential use in the assessment of chronic mitochondrial toxicity

Despite being widely applied in drug development, existing in vitro 2D cell-based models are not suitable to assess chronic mitochondrial toxicity. A novel in vitro assay system mimicking in vivo microenvironment for this purpose is urgently needed. The goal of this study is to establish a 3D cell p...

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Detalles Bibliográficos
Autores principales: Ding, Huifen, George, Sunil, Leng, Xiaoyan Iris, Ihnat, Michael, Ma, Jian-Xing, Jiang, Guochun, Margolis, David, Dumond, Julie, Zhang, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542430/
https://www.ncbi.nlm.nih.gov/pubmed/36212078
http://dx.doi.org/10.1016/j.mtadv.2022.100261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542430/
https://www.ncbi.nlm.nih.gov/pubmed/36212078
http://dx.doi.org/10.1016/j.mtadv.2022.100261

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