Calcium dobesilate reduces SARS-CoV-2 entry into endothelial cells by inhibiting virus binding to heparan sulfate

Recent reports demonstrate that SARS-CoV-2 utilizes cell surface heparan sulfate as an attachment factor to facilitate the initial interaction with host cells. Heparan sulfate interacts with the receptor binding domain of SARS-CoV-2 spike glycoprotein, and blocking this interaction can decrease cell...

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Detalles Bibliográficos
Autores principales: Kiyan, Yulia, Schultalbers, Anna, Chernobrivaia, Ekaterina, Tkachuk, Sergey, Rong, Song, Shushakova, Nelli, Haller, Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542452/
https://www.ncbi.nlm.nih.gov/pubmed/36207386
http://dx.doi.org/10.1038/s41598-022-20973-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542452/
https://www.ncbi.nlm.nih.gov/pubmed/36207386
http://dx.doi.org/10.1038/s41598-022-20973-3

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