Could Amyloid-β 1–42 or α-Synuclein Interact Directly with Mitochondrial DNA? A Hypothesis

[Image: see text] The amyloid β (Aβ) and the α-synuclein (α-syn) are shown to be translocated into mitochondria. Even though their roles are widely investigated in pathological conditions, information on the presence and functions of Aβ and α-syn in mitochondria in endogenous levels is somewhat limi...

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Autores principales: Gezen-Ak, Duygu, Yurttaş, Zuhal, Çamoǧlu, Tugay, Dursun, Erdinç
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542719/
https://www.ncbi.nlm.nih.gov/pubmed/36125124
http://dx.doi.org/10.1021/acschemneuro.2c00512
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author Gezen-Ak, Duygu
Yurttaş, Zuhal
Çamoǧlu, Tugay
Dursun, Erdinç
author_facet Gezen-Ak, Duygu
Yurttaş, Zuhal
Çamoǧlu, Tugay
Dursun, Erdinç
author_sort Gezen-Ak, Duygu
collection PubMed
description [Image: see text] The amyloid β (Aβ) and the α-synuclein (α-syn) are shown to be translocated into mitochondria. Even though their roles are widely investigated in pathological conditions, information on the presence and functions of Aβ and α-syn in mitochondria in endogenous levels is somewhat limited. We hypothesized that endogenous Aβ fragments or α-syn could interact with mitochondrial DNA (mtDNA) directly or influence RNAs or transcription factors in mitochondria and change the mtDNA transcription profile. In this review, we summarized clues of these possible interactions.
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spelling pubmed-95427192022-10-08 Could Amyloid-β 1–42 or α-Synuclein Interact Directly with Mitochondrial DNA? A Hypothesis Gezen-Ak, Duygu Yurttaş, Zuhal Çamoǧlu, Tugay Dursun, Erdinç ACS Chem Neurosci [Image: see text] The amyloid β (Aβ) and the α-synuclein (α-syn) are shown to be translocated into mitochondria. Even though their roles are widely investigated in pathological conditions, information on the presence and functions of Aβ and α-syn in mitochondria in endogenous levels is somewhat limited. We hypothesized that endogenous Aβ fragments or α-syn could interact with mitochondrial DNA (mtDNA) directly or influence RNAs or transcription factors in mitochondria and change the mtDNA transcription profile. In this review, we summarized clues of these possible interactions. American Chemical Society 2022-09-20 /pmc/articles/PMC9542719/ /pubmed/36125124 http://dx.doi.org/10.1021/acschemneuro.2c00512 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Gezen-Ak, Duygu
Yurttaş, Zuhal
Çamoǧlu, Tugay
Dursun, Erdinç
Could Amyloid-β 1–42 or α-Synuclein Interact Directly with Mitochondrial DNA? A Hypothesis
title Could Amyloid-β 1–42 or α-Synuclein Interact Directly with Mitochondrial DNA? A Hypothesis
title_full Could Amyloid-β 1–42 or α-Synuclein Interact Directly with Mitochondrial DNA? A Hypothesis
title_fullStr Could Amyloid-β 1–42 or α-Synuclein Interact Directly with Mitochondrial DNA? A Hypothesis
title_full_unstemmed Could Amyloid-β 1–42 or α-Synuclein Interact Directly with Mitochondrial DNA? A Hypothesis
title_short Could Amyloid-β 1–42 or α-Synuclein Interact Directly with Mitochondrial DNA? A Hypothesis
title_sort could amyloid-β 1–42 or α-synuclein interact directly with mitochondrial dna? a hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542719/
https://www.ncbi.nlm.nih.gov/pubmed/36125124
http://dx.doi.org/10.1021/acschemneuro.2c00512
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