Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome multidrug resistance in cancer cells

Multidrug resistance (MDR) is a leading cause for treatment failure in cancer patients. One of the reasons of MDR is drug efflux by ATP-binding cassette (ABC) transporters in eukaryotic cells especially ABCB1 (P-glycoprotein). In this study, certain novel 1,2,5-trisubstituted benzimidazole derivativ...

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Detalles Bibliográficos
Autores principales: Abdelhafiz, Abeer H. A., Serya, Rabah A. T., Lasheen, Deena S., Wang, Nessa, Sobeh, Mansour, Wink, Michael, Abouzid, Khaled A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543179/
https://www.ncbi.nlm.nih.gov/pubmed/36168121
http://dx.doi.org/10.1080/14756366.2022.2127700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543179/
https://www.ncbi.nlm.nih.gov/pubmed/36168121
http://dx.doi.org/10.1080/14756366.2022.2127700

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