Structural and ITC Characterization of Peptide‐Protein Binding: Thermodynamic Consequences of Cyclization Constraints, a Case Study on Vascular Endothelial Growth Factor Ligands

Macrocyclization constraints are widely used in the design of protein ligands to stabilize their bioactive conformation and increase their affinities. However, the resulting changes in binding entropy can be puzzling and uncorrelated to affinity gains. Here, the thermodynamic (Isothermal Titration C...

Descripción completa

Detalles Bibliográficos
Autores principales: Gaucher, Jean‐François, Reille‐Seroussi, Marie, Broussy, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543606/
https://www.ncbi.nlm.nih.gov/pubmed/35665969
http://dx.doi.org/10.1002/chem.202200465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543606/
https://www.ncbi.nlm.nih.gov/pubmed/35665969
http://dx.doi.org/10.1002/chem.202200465

Ejemplares similares