Lewy Body–like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α‐Synuclein Mutations

OBJECTIVE: We utilized human midbrain‐like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α‐synuclein (α‐syn; SNCA) perturbations to investigate genotype‐to‐phenotype relationships in Parkinson disease, with the particular aim of recapitulat...

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Detalles Bibliográficos
Autores principales: Jo, Junghyun, Yang, Lin, Tran, Hoang‐Dai, Yu, Weonjin, Sun, Alfred Xuyang, Chang, Ya Yin, Jung, Byung Chul, Lee, Seung‐Jae, Saw, Tzuen Yih, Xiao, Bin, Khoo, Audrey Tze Ting, Yaw, Lai‐Ping, Xie, Jessica Jiaxin, Lokman, Hidayat, Ong, Wei‐Yi, Lim, Grace Gui Yin, Lim, Kah‐Leong, Tan, Eng‐King, Ng, Huck‐Hui, Je, Hyunsoo Shawn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543721/
https://www.ncbi.nlm.nih.gov/pubmed/34288055
http://dx.doi.org/10.1002/ana.26166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543721/
https://www.ncbi.nlm.nih.gov/pubmed/34288055
http://dx.doi.org/10.1002/ana.26166

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