Cargando…

Lewy Body–like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α‐Synuclein Mutations

OBJECTIVE: We utilized human midbrain‐like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α‐synuclein (α‐syn; SNCA) perturbations to investigate genotype‐to‐phenotype relationships in Parkinson disease, with the particular aim of recapitulat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jo, Junghyun, Yang, Lin, Tran, Hoang‐Dai, Yu, Weonjin, Sun, Alfred Xuyang, Chang, Ya Yin, Jung, Byung Chul, Lee, Seung‐Jae, Saw, Tzuen Yih, Xiao, Bin, Khoo, Audrey Tze Ting, Yaw, Lai‐Ping, Xie, Jessica Jiaxin, Lokman, Hidayat, Ong, Wei‐Yi, Lim, Grace Gui Yin, Lim, Kah‐Leong, Tan, Eng‐King, Ng, Huck‐Hui, Je, Hyunsoo Shawn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543721/ https://www.ncbi.nlm.nih.gov/pubmed/34288055 http://dx.doi.org/10.1002/ana.26166

Ejemplares similares

Glucocerebrosidase Gene Therapy Induces Alpha-Synuclein Clearance and Neuroprotection of Midbrain Dopaminergic Neurons in Mice and Macaques
por: Sucunza, Diego, et al.
Publicado: (2021)

Ambroxol effects in glucocerebrosidase and α‐synuclein transgenic mice
por: Migdalska‐Richards, Anna, et al.
Publicado: (2016)

Did α-Synuclein and Glucocerebrosidase Coevolve? Implications for Parkinson’s Disease
por: Gruschus, James M.
Publicado: (2015)

Glucocerebrosidase Mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease
por: Kurzawa-Akanbi, Marzena, et al.
Publicado: (2012)

Selective loss of glucocerebrosidase activity in sporadic Parkinson’s disease and dementia with Lewy bodies
por: Chiasserini, Davide, et al.
Publicado: (2015)

A severe neurodegenerative disease with Lewy bodies and a mutation in the glucocerebrosidase gene
por: Sipilä, Jussi O. T., et al.
Publicado: (2023)

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration
por: Davis, Marie Y., et al.
Publicado: (2016)

Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation
por: Bae, Eun-Jin, et al.
Publicado: (2015)

Glucocerebrosidase deficiency promotes release of α-synuclein fibrils from cultured neurons
por: Gegg, Matthew E, et al.
Publicado: (2020)

Dermal Phospho-Alpha-Synuclein Deposition in Patients With Parkinson's Disease and Mutation of the Glucocerebrosidase Gene
por: Doppler, Kathrin, et al.
Publicado: (2018)

Intestine-derived α-synuclein initiates and aggravates pathogenesis of Parkinson’s disease in Drosophila
por: Liu, Wei, et al.
Publicado: (2022)

Glucocerebrosidase mRNA is Diminished in Brain of Lewy Body Diseases and Changes with Disease Progression in Blood
por: Perez-Roca, Laia, et al.
Publicado: (2018)

Loss of β-Glucocerebrosidase Activity Does Not Affect Alpha-Synuclein Levels or Lysosomal Function in Neuronal Cells
por: Dermentzaki, Georgia, et al.
Publicado: (2013)

Biochemical consequences of glucocerebrosidase 1 mutations in Parkinson’s disease
por: Yoon, Jeong Hyun, et al.
Publicado: (2023)

Comparative hepatoprotective effects of tocotrienol analogs against drug-induced liver injury
por: Tan, Cheau Yih, et al.
Publicado: (2015)

Correction: Loss of β-Glucocerebrosidase Activity Does Not Affect Alpha-Synuclein Levels or Lysosomal Function in Neuronal Cells
por: Dermentzaki, Georgia, et al.
Publicado: (2021)

Alpha-synuclein biology in Lewy body diseases
por: Kim, Woojin Scott, et al.
Publicado: (2014)

Parkinsonisms and Glucocerebrosidase Deficiency: A Comprehensive Review for Molecular and Cellular Mechanism of Glucocerebrosidase Deficiency
por: Gatto, Emilia M., et al.
Publicado: (2019)

The Exosomal/Total α-Synuclein Ratio in Plasma Is Associated With Glucocerebrosidase Activity and Correlates With Measures of Disease Severity in PD Patients
por: Cerri, Silvia, et al.
Publicado: (2018)

Parkinsonism Associated with Glucocerebrosidase Mutation
por: Sunwoo, Mun-Kyung, et al.
Publicado: (2011)

Glucocerebrosidase mutations in primary parkinsonism
por: Asselta, Rosanna, et al.
Publicado: (2014)

Glucocerebrosidase: Functions in and Beyond the Lysosome
por: Boer, Daphne E.C., et al.
Publicado: (2020)

Glucocerebrosidase mutations and Parkinson disease
por: Vieira, Sophia R. L., et al.
Publicado: (2022)

Alpha-synuclein oligomers alter the spontaneous firing discharge of cultured midbrain neurons
por: Tomagra, Giulia, et al.
Publicado: (2023)

AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression
por: Hang, Liting, et al.
Publicado: (2018)

Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice
por: Rocha, Emily M., et al.
Publicado: (2015)

Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology
por: Navarro-Romero, Alba, et al.
Publicado: (2022)

Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice
por: Yu, Weonjin, et al.
Publicado: (2019)

Midbrain catecholaminergic neurons co-express α-synuclein and tau in progressive supranuclear palsy
por: Erro Aguirre, María Elena, et al.
Publicado: (2015)

Corrigendum: Alpha-synuclein oligomers alter the spontaneous firing discharge of cultured midbrain neurons
por: Tomagra, Giulia, et al.
Publicado: (2023)

Novel pathogenic mutations in the glucocerebrosidase locus
por: Duran, Raquel, et al.
Publicado: (2012)

Mitochondrial dysfunction associated with glucocerebrosidase deficiency
por: Gegg, Matthew E., et al.
Publicado: (2016)

Glucocerebrosidase and its relevance to Parkinson disease
por: Do, Jenny, et al.
Publicado: (2019)

Stabilization of Glucocerebrosidase by Active Site Occupancy
por: Ben Bdira, Fredj, et al.
Publicado: (2017)

Neurological effects of glucocerebrosidase gene mutations
por: Mullin, S., et al.
Publicado: (2018)

α-Synuclein as CSF and Blood Biomarker of Dementia with Lewy Bodies
por: Kasuga, Kensaku, et al.
Publicado: (2012)

Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage
por: Cleeter, Michael W.J., et al.
Publicado: (2013)

Silencing of Glucocerebrosidase Gene in Drosophila Enhances the Aggregation of Parkinson's Disease Associated α-Synuclein Mutant A53T and Affects Locomotor Activity
por: Abul Khair, Salema B., et al.
Publicado: (2018)

Alpha-synuclein is strategically positioned for afferent modulation of midbrain dopamine neurons and is essential for cocaine preference
por: Trubetckaia, Olga, et al.
Publicado: (2019)

The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson’s Disease
por: Minakaki, Georgia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rec3bi7vpao4h8m1k0juhnan22