Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes

The crystal structures of cattleyene synthase (apo‐CyS), and CyS complexed with geranylgeranyl pyrophosphate (GGPP) were solved. The CyS(C59A) variant exhibited an increased production of cattleyene and other diterpenes with diverse skeletons. Its structure showed a widened active site cavity explai...

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Detalles Bibliográficos
Autores principales: Xing, Baiying, Xu, Houchao, Li, Annan, Lou, Tingting, Xu, Meng, Wang, Kaibiao, Xu, Zhengren, Dickschat, Jeroen S., Yang, Donghui, Ma, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543850/
https://www.ncbi.nlm.nih.gov/pubmed/35819825
http://dx.doi.org/10.1002/anie.202209785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543850/
https://www.ncbi.nlm.nih.gov/pubmed/35819825
http://dx.doi.org/10.1002/anie.202209785

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