A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress

Partial loss-of-function mutations in glycosylation pathways underlie a set of rare diseases called Congenital Disorders of Glycosylation (CDGs). In particular, DPAGT1-CDG is caused by mutations in the gene encoding the first step in N-glycosylation, DPAGT1, and this disorder currently lacks effecti...

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Detalles Bibliográficos
Autores principales: Dalton, Hans M., Viswanatha, Raghuvir, Brathwaite, Roderick, Zuno, Jae Sophia, Berman, Alexys R., Rushforth, Rebekah, Mohr, Stephanie E., Perrimon, Norbert, Chow, Clement Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543880/
https://www.ncbi.nlm.nih.gov/pubmed/36166480
http://dx.doi.org/10.1371/journal.pgen.1010430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543880/
https://www.ncbi.nlm.nih.gov/pubmed/36166480
http://dx.doi.org/10.1371/journal.pgen.1010430

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