Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification

A rationally‐designed scaffold of cyclic octapeptides composed of two units of the natural tripeptide glutathione (GSH) was optimized to strongly and selectively capture toxic lead ions (Pb(II)). Using state‐of‐the‐art computational tools, a list of eleven plausible peptides was shortened to five an...

Descripción completa

Detalles Bibliográficos
Autores principales: Sauser, Luca, Kalvoda, Tadeáš, Kavas, Ayça, Rulíšek, Lubomír, Shoshan, Michal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544108/
https://www.ncbi.nlm.nih.gov/pubmed/35560783
http://dx.doi.org/10.1002/cmdc.202200152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544108/
https://www.ncbi.nlm.nih.gov/pubmed/35560783
http://dx.doi.org/10.1002/cmdc.202200152

Ejemplares similares