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Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification
A rationally‐designed scaffold of cyclic octapeptides composed of two units of the natural tripeptide glutathione (GSH) was optimized to strongly and selectively capture toxic lead ions (Pb(II)). Using state‐of‐the‐art computational tools, a list of eleven plausible peptides was shortened to five an...
Autores principales: | Sauser, Luca, Kalvoda, Tadeáš, Kavas, Ayça, Rulíšek, Lubomír, Shoshan, Michal S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544108/ https://www.ncbi.nlm.nih.gov/pubmed/35560783 http://dx.doi.org/10.1002/cmdc.202200152 |
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