Cargando…

Application of metabolite set enrichment analysis on untargeted metabolomics data prioritises relevant pathways and detects novel biomarkers for inherited metabolic disorders

Untargeted metabolomics (UM) allows for the simultaneous measurement of hundreds of metabolites in a single analytical run. The sheer amount of data generated in UM hampers its use in patient diagnostics because manual interpretation of all features is not feasible. Here, we describe the application...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoegen, Brechtje, Hampstead, Juliet E., Engelke, Udo F.H., Kulkarni, Purva, Wevers, Ron A., Brunner, Han G., Coene, Karlien L. M., Gilissen, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544878/ https://www.ncbi.nlm.nih.gov/pubmed/35546254 http://dx.doi.org/10.1002/jimd.12522

Ejemplares similares

Variable Selection in Untargeted Metabolomics and the Danger of Sparsity
por: Tinnevelt, Gerjen H., et al.
Publicado: (2020)

Metabolomics-Based Screening of Inborn Errors of Metabolism: Enhancing Clinical Application with a Robust Computational Pipeline
por: Hoegen, Brechtje, et al.
Publicado: (2021)

Next-generation metabolic screening: targeted and untargeted metabolomics for the diagnosis of inborn errors of metabolism in individual patients
por: Coene, Karlien L. M., et al.
Publicado: (2018)

Confirmation of neurometabolic diagnoses using age‐dependent cerebrospinal fluid metabolomic profiles
por: Peters, Tessa M. A., et al.
Publicado: (2020)

Unraveling the unknown areas of the human metabolome: the role of infrared ion spectroscopy
por: Martens, Jonathan, et al.
Publicado: (2018)

A comparison of high-throughput plasma NMR protocols for comparative untargeted metabolomics
por: Bliziotis, Nikolaos G., et al.
Publicado: (2020)

Benchmarking Outlier Detection Methods for Detecting IEM Patients in Untargeted Metabolomics Data
por: Bongaerts, Michiel, et al.
Publicado: (2023)

metPropagate: network-guided propagation of metabolomic information for prioritization of metabolic disease genes
por: Graham Linck, Emma J., et al.
Publicado: (2020)

A diagnostic biomarker profile for fibromyalgia syndrome based on an NMR metabolomics study of selected patients and controls
por: Malatji, Bontle G., et al.
Publicado: (2017)

Targeted urine metabolomics with a graphical reporting tool for rapid diagnosis of inborn errors of metabolism
por: Steinbusch, Laura K.M., et al.
Publicado: (2021)

Pre- versus post-operative untargeted plasma nuclear magnetic resonance spectroscopy metabolomics of pheochromocytoma and paraganglioma
por: Bliziotis, Nikolaos G., et al.
Publicado: (2021)

Preanalytical Pitfalls in Untargeted Plasma Nuclear Magnetic Resonance Metabolomics of Endocrine Hypertension
por: Bliziotis, Nikolaos G., et al.
Publicado: (2022)

Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome
por: Hsu, Yu-Han H., et al.
Publicado: (2020)

Molecular identification in metabolomics using infrared ion spectroscopy
por: Martens, Jonathan, et al.
Publicado: (2017)

A hypothetical astrocyte–microglia lactate shuttle derived from a (1)H NMR metabolomics analysis of cerebrospinal fluid from a cohort of South African children with tuberculous meningitis
por: Mason, Shayne, et al.
Publicado: (2014)

Improved batch correction in untargeted MS-based metabolomics
por: Wehrens, Ron, et al.
Publicado: (2016)

Effect of DHA-Enriched Phospholipids from Fish Roe on Rat Fecal Metabolites: Untargeted Metabolomic Analysis
por: Lu, Xiaodan, et al.
Publicado: (2023)

Untargeted Metabolomic Characterization of Ovarian Tumors
por: Liu, Xiaona, et al.
Publicado: (2020)

Editorial: Advances and challenges in untargeted metabolomics
por: Wawrzyniak, Renata, et al.
Publicado: (2023)

Metabolite Identification Using Infrared Ion Spectroscopy—Novel Biomarkers for Pyridoxine-Dependent Epilepsy
por: van Outersterp, Rianne E., et al.
Publicado: (2021)

New plasma preparation approach to enrich metabolome coverage in untargeted metabolomics: plasma protein bound hydrophobic metabolite release with proteinase K
por: Wawrzyniak, Renata, et al.
Publicado: (2018)

Nicotinamide Riboside Improves Ataxia Scores and Immunoglobulin Levels in Ataxia Telangiectasia
por: Veenhuis, Stefanie J.G., et al.
Publicado: (2021)

Distinguishing Oligosaccharide Isomers Using Far-Infrared Ion Spectroscopy: Identification of Biomarkers for Inborn Errors of Metabolism
por: van Outersterp, Rianne E., et al.
Publicado: (2023)

Untargeted Metabolomics To Ascertain Antibiotic Modes of Action
por: Vincent, Isabel M., et al.
Publicado: (2016)

Discovery of Pancreatic Adenocarcinoma Biomarkers by Untargeted Metabolomics
por: Martín-Blázquez, Ariadna, et al.
Publicado: (2020)

Current Practice in Untargeted Human Milk Metabolomics
por: Ten-Doménech, Isabel, et al.
Publicado: (2020)

Targeted and untargeted metabolomic approach for GDM diagnosis
por: Burzynska-Pedziwiatr, Izabela, et al.
Publicado: (2023)

An Untargeted Metabolomics Approach on Carfilzomib-Induced Nephrotoxicity
por: Barla, Ioanna, et al.
Publicado: (2022)

Optimized Metabolomic Approach to Identify Uremic Solutes in Plasma of Stage 3–4 Chronic Kidney Disease Patients
por: Mutsaers, Henricus A. M., et al.
Publicado: (2013)

The 3-methylglutaconic acidurias: what’s new?
por: Wortmann, Saskia B., et al.
Publicado: (2010)

Towards the Disease Biomarker in an Individual Patient Using Statistical Health Monitoring
por: Engel, Jasper, et al.
Publicado: (2014)

Comparison of Widely Targeted Metabolomics and Untargeted Metabolomics of Wild Ophiocordyceps sinensis
por: Zhou, Jinna, et al.
Publicado: (2022)

Untargeted Metabolomic Approach to Study the Impact of Aging on Salivary Metabolome in Women
por: Bosman, Pauline, et al.
Publicado: (2022)

Integration of genomics and metabolomics for prioritization of rare disease variants: a 2018 literature review
por: Graham, Emma, et al.
Publicado: (2018)

Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes
por: Dawed, Adem Y., et al.
Publicado: (2017)

Analytical Methods in Untargeted Metabolomics: State of the Art in 2015
por: Alonso, Arnald, et al.
Publicado: (2015)

Dissecting Bottromycin Biosynthesis Using Comparative Untargeted Metabolomics
por: Crone, William J. K., et al.
Publicado: (2016)

Filtering procedures for untargeted LC-MS metabolomics data
por: Schiffman, Courtney, et al.
Publicado: (2019)

Untargeted metabolomics yields insight into ALS disease mechanisms
por: Goutman, Stephen A, et al.
Publicado: (2020)

Inborn Errors of Metabolism in the Era of Untargeted Metabolomics and Lipidomics
por: Ismail, Israa T, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_e7na57hl47msae9k1dres5sio9