The Evaluation of l‐Tryptophan Derivatives as Inhibitors of the l‐Type Amino Acid Transporter LAT1 (SLC7A5)

A series of derivatives of the substrate amino acid l‐tryptophan have been investigated for inhibition of the L‐type amino acid transporter LAT1 (SLC7A5), which is an emerging target in anticancer drug discovery. Of the four isomeric 4‐, 5‐, 6‐, or 7‐benzyloxy‐l‐tryptophans, the 5‐substituted deriva...

Descripción completa

Detalles Bibliográficos
Autores principales: Graff, Julien, Müller, Jennifer, Sadurní, Anna, Rubin, Matthias, Canivete Cuissa, Inês André, Keller, Claudia, Hartmann, Marco, Singer, Simon, Gertsch, Jürg, Altmann, Karl‐Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545129/
https://www.ncbi.nlm.nih.gov/pubmed/35895286
http://dx.doi.org/10.1002/cmdc.202200308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545129/
https://www.ncbi.nlm.nih.gov/pubmed/35895286
http://dx.doi.org/10.1002/cmdc.202200308

Ejemplares similares